Beta-caryophyllene is a terpene, which is a type of organic compound found in various plants, including cannabis. It is known for its distinctive spicy, peppery, and woody aroma and flavor.

One notable aspect of beta-caryophyllene is its interaction with the body’s endocannabinoid system (ECS). Unlike most terpenes, beta-caryophyllene acts as a cannabinoid because it selectively binds to the CB2 receptors of the ECS, which are primarily found in immune cells and peripheral tissues. This makes beta-caryophyllene unique among terpenes in its ability to directly influence the ECS.

Beta-caryophyllene is found not only in cannabis but also in other plants, including black pepper, cloves, and certain herbs and spices. Its presence in cannabis contributes to the overall aroma and flavor profile of different strains and may also contribute to the entourage effect, where the combination of various cannabinoids and terpenes produces enhanced therapeutic effects compared to isolated compounds.

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