CB1 receptors, or cannabinoid receptor type 1, are a type of G protein-coupled receptor (GPCR) found primarily in the central nervous system (CNS), including the brain and spinal cord. They are one of the two main types of cannabinoid receptors, with the other being CB2 receptors.
CB1 receptors play a key role in the endocannabinoid system, a complex signaling system involved in regulating various physiological processes throughout the body, including mood, memory, pain sensation, appetite, and motor control.
CB1 receptors are of significant interest in medical research due to their involvement in regulating various physiological processes and their potential as therapeutic targets for conditions such as chronic pain, epilepsy, multiple sclerosis, anxiety disorders, and neurodegenerative diseases. However, targeting CB1 receptors for therapeutic purposes also carries the risk of adverse effects, which must be carefully considered in drug development and clinical use.